Abcam, ab204164, Recombinant human ANKK1 protein

Size: 5µg / 10µg
Recombinant human ANKK1 protein is a Human Full Length protein, in the 1 to 765 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, FuncS, WB.
Key facts
Purity:>75% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The Specific activity of ab204164 was determined to be 80 nmol/min/mg.,
Accession:Q8NFD2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Product details:
ab64311
(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKK1 also known as Ankyrin repeat and kinase domain containing 1 is a protein encoded by the ANKK1 gene. This protein has a molecular mass of approximately 78 kDa. ANKK1 is expressed in various tissues with notable expression in the brain. It consists of both ankyrin repeat domains which facilitate protein-protein interactions and a serine/threonine kinase domain which is responsible for its kinase activity.
Biological function summary
ANKK1 participates in signal transduction by influencing dopamine receptor signaling pathways. It does not work alone and is often part of protein complexes that regulate cellular responses. Through its kinase activity ANKK1 affects phosphorylation processes thereby modulating receptor function and neuronal communication. This protein plays a fundamental role in brain function and behavior linking its activity to several neurological processes.
Pathways
ANKK1 interacts with molecular players influencing the dopaminergic signaling pathway which is important for reward motivation and motor control. ANKK1 is associated with DRD2 the dopamine receptor D2 to regulate responses to dopamine. Additionally this protein finds indirect connections with the cAMP signaling pathway influencing cyclic AMP levels and consequently cell signaling efficacy.
ANKK1 has been connected to schizophrenia and addiction. Variants in the ANKK1 gene have shown strong correlations with the risk of developing schizophrenia possibly due to its impact on dopaminergic pathways and DRD2 receptor regulation. Another significant association lies in addiction disorders where ANKK1 variants affect dopamine neurotransmission highlighting the complex interplay with the DRD2 receptor. These associations highlight its relevance in neuropsychiatric research and potential therapeutic targeting.