Abcam, ab204173, Anti-EDEM2 antibody

Size: 100µL
Rabbit Polyclonal EDEM2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EDEM2 aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EDEM2 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q9BV94

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein EDEM2 is an important part of endoplasmic reticulum-associated degradation (ERAD). It also goes by the name ER degradation-enhancing alpha-mannosidase-like protein 2. This protein is about 66 kDa in mass. EDEM2 is mostly expressed in cells within the endoplasmic reticulum where it carries out its main function. The protein helps in recognizing misfolded glycoproteins and it plays a role in the removal of terminal mannose residues which is necessary for processing and degradation.
Biological function summary
EDEM2 helps ensure protein quality control within cells. It works as part of the ERAD system by targeting misfolded glycoproteins for degradation preventing accumulation of defective proteins that could be harmful to cells. EDEM2 does not act alone but instead functions together with other molecular chaperones and lectin-like proteins to identify and process substrates. This cooperation is essential for maintaining cellular homeostasis and avoiding stress responses.
Pathways
EDEM2 links closely with both protein foldings and quality control mechanisms. It directly interacts with ERAD pathways promoting the disassembly of structurally improper glycoproteins. The action of EDEM2 in these pathways connects with other proteins like SEL1L and HRD1 forming a network that handles aberrant proteins.
EDEM2's role in ERAD pathways relates to conditions like cystic fibrosis and certain neurodegenerative diseases. Misfolded proteins are a known feature in these diseases and EDEM2’s function is essential for managing such protein folding errors. Problems in the activity of EDEM2 or related proteins like OS9 can potentially exacerbate these conditions highlighting the importance of EDEM2 in disease management and potential therapeutic approaches.