Abcam, ab204348, Anti-ASCT-1 antibody

Size: 100µL
Rabbit Polyclonal ASCT-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC1A4 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC1A4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P43007

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Alanine Serine Cysteine-preferring Transporter 1 (ASCT-1) also known as SLC1A4 functions as a Na+-dependent transport protein for neutral amino acids including alanine serine and cysteine. It has a molecular mass of approximately 56 kDa. ASCT-1 expresses on the plasma membrane and is found in the brain and the retina. Its role in the transport of certain amino acids is critical for maintaining normal cellular functions and metabolic processes.
Biological function summary
ASCT-1 transports amino acids which contributes to cellular nutrition and neurotransmitter cycling. It does not function as part of a larger protein complex but rather as a standalone transporter. ASCT-1 plays a significant role in neuronal health by regulating amino acids in the synaptic cleft which impacts neurotransmitter synthesis and recycling essential for proper neural communication.
Pathways
ASCT-1 is actively involved in the glutamate cycle which maintains neurotransmitter homeostasis in the brain. Its activity facilitates the uptake of serine used in the synthesis of D-serine an important co-agonist in NMDA receptor pathways. Both the ASCT-2 transporter and SLC1A3 also part of the glutamate transporter family share related functions in these pathways ensuring the synaptic glutamate levels are regulated effectively.
ASCT-1 mutations or dysregulation have links to neurodevelopmental disorders including intellectual disability and epilepsy. Alterations in its function disrupt amino acid transport which can affect neurotransmitter cycling contributing to these conditions. Additionally ASCT-1 shares a connection with SLC1A5 in these disorders where overlapping functions in amino acid transport may exacerbate the symptoms when mutated or dysfunctional.