Abcam, ab204420, Anti-C12orf10 antibody

Size: 100µL
Rabbit Polyclonal C12orf10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYG1 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYG1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9HB07

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C12orf10 also known as MGC54262 is a protein encoded by the C12orf10 gene. The protein has a molecular mass of approximately 20 kDa. It is expressed in several tissues with notable expression in the liver and kidney. Mechanically C12orf10 is involved in intracellular processes although detailed mechanisms are not yet fully understood. The protein localizes within the cytoplasm and may play a role in cellular transport or signaling given its distribution.
Biological function summary
C12orf10 participates in cellular processes that regulate cell growth and differentiation. While not yet fully characterized as part of a larger complex it may interact with other proteins involved in signal transduction. These interactions suggest that C12orf10 could influence cellular communication and the response to extracellular signals. The precise biological implications remain an active area of research aiming to reveal more about how it affects cellular functions.
Pathways
C12orf10 seems to be involved in pathways that pertain to cellular signaling and metabolic regulation. Specifically it likely interacts within the MAPK pathway where it may link to proteins like MEK1/2 which are important in transmitting signals from the cell membrane to the nucleus. This pathway affects cell fate decisions which highlights the role of C12orf10 in cell proliferation and survival. Another potential pathway is the insulin signaling pathway where C12orf10 might influence glucose metabolism highlighting its role in energy balance and cellular homeostasis.
C12orf10 has been associated with metabolic disorders such as diabetes due to its involvement in glucose regulation pathways. The protein's potential interaction with insulin receptor substrate proteins makes it a point of interest in understanding insulin resistance and metabolic syndrome. Additionally there is emerging evidence linking C12orf10 to certain liver diseases including non-alcoholic fatty liver disease (NAFLD). This connection may involve interactions with proteins like AMPK which are important regulators of energy homeostasis and lipid metabolism. Further research is needed to clarify these associations and the therapeutic potential of targeting C12orf10 in these conditions.