Abcam, ab204743, Anti-ARHGAP22 antibody

Size: 100µL
Rabbit Polyclonal ARHGAP22 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP22 aa 450-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP22 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.Q7Z5H3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP22 also known as Rho GTPase-activating protein 22 functions as a critical regulator of Rho family GTPases through GTPase activation which leads to the inactivation of RhoC and Cdc42. This protein includes the unique domains required for its GTPase-activating role and has a molecular mass of approximately 75 kDa. ARHGAP22 predominantly expresses in tissues such as the brain kidney and spleen.
Biological function summary
ARHGAP22 modulates actin organization which affects cell shape and motility. It plays a role in the regulation of cell migration and cytoskeleton dynamics. Though not part of a well-defined multiprotein complex ARHGAP22 interacts with other proteins involved in cytoskeletal rearrangement supporting cellular communication and migration processes.
Pathways
ARHGAP22 integrates into signaling cascades like the Rho GTPase cycle influencing cell migration pathways. It interacts with proteins such as RhoC and Cdc42 within these pathways contributing to dynamic cellular remodeling. The pathways linked to ARHGAP22 involve cytoskeletal reorganization affecting processes like angiogenesis and neural development.
ARHGAP22 has implications in cancer progression particularly through its role in metastasis. Overexpression or misregulation can contribute to enhanced cell migration and invasion leading to a more aggressive cancer phenotype. Additionally ARHGAP22 is connected to neurological disorders possibly through its impact on neural cell migration. Interaction with proteins such as Cdc42 can disrupt normal signaling leading to these pathological conditions.