Abcam, ab204841, Anti-PEX13 antibody

Size: 100µL
Rabbit Polyclonal PEX13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX13 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PEX13 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q92968

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PEX13 also called peroxin-13 is a protein involved in peroxisomal biogenesis. This protein has a molecular mass of approximately 42 kDa. PEX13 is expressed mainly in tissues that have a significant peroxisomal content such as the liver and kidney. It forms part of the peroxisome membrane where it facilitates the import of proteins into the peroxisome matrix. This process is essential for maintaining proper peroxisome function which plays a role in lipid metabolism and reactive oxygen species detoxification.
Biological function summary
PEX13 participates in the assembly of the peroxisomal importomer complex a multi-protein structure essential for peroxisomal matrix protein import. PEX13 interacts with other peroxins such as PEX14 and PEX5 to mediate the docking and translocation of cargo proteins that bear peroxisomal targeting signals. This process ensures that proteins required for peroxisomal functions are correctly imported impacting cellular homeostasis.
Pathways
PEX13 plays a role in peroxisome biogenesis and functioning pathways. In the peroxisome biogenesis pathway PEX13 directly interacts with other peroxins like PEX14 to assist in the formation and maintenance of functional peroxisomes. Alongside its interaction with PEX5 PEX13 is important in pathways facilitating the import of enzymes necessary for fatty acid beta-oxidation and hydrogen peroxide detoxification within peroxisomes.
PEX13 mutations are linked to Zellweger spectrum disorders a group of peroxisome biogenesis disorders. These conditions impair normal peroxisomal functions leading to severe developmental and neurological defects. Additionally some cases of neonatal adrenoleukodystrophy have associations with PEX13 dysfunction highlighting its role in peroxisome-related metabolic pathways. The disruption in PEX13 function in these disorders often involves its interactions with proteins such as PEX14 and PEX5 leading to improper protein import and peroxisomal dysfunction.