Abcam, ab204846, Anti-AIM1 antibody

Size: 100µL
Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRYBG1 aa 700-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CRYBG1 aa 700-850. The exact immunogen used to generate this antibody is proprietary information.Q9Y4K1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The AIM1 protein also known as Absent In Melanoma 1 has roles in various cellular processes. It is commonly identified in multiple tissues including the skin and the eyes where it contributes to cellular stability and function. AIM1 has a molecular mass of around 69 kilodaltons. Its expression patterns suggest it plays significant roles in cellular microenvironment and differentiation especially in melanocytes and ocular cells. Expression levels may vary affecting cellular activities accordingly.
Biological function summary
AIM1 associates with structures that include the cytoskeleton indicating its potential role in maintaining cell shape and motility. It has binding capabilities that aid in cellular assembly processes. AIM1 does not usually operate as part of a larger protein complex but influences intracellular signaling indirectly. Its involvement in cell stability further implies a role in developmental pathways possibly impacting cellular proliferation and differentiation outcomes in melanocytes.
Pathways
AIM1 interacts with signaling pathways related to cellular differentiation and proliferation. It plays a part in the regulation of actin cytoskeleton pathways where it influences cellular architecture and movement. In these pathways proteins like Rho family GTPases may relate to AIM1 impacting downstream signaling events. Such interactions highlight AIM1’s influence on dynamic cellular changes and stability.
AIM1 shows links to melanoma and retinal diseases. In melanoma AIM1 expression often changes suggesting it may contribute to the aggressive behavior of melanocytes when dysregulated. Connections to ocular proteins like CRX suggest that AIM1 may also play a part in some retinal degenerative conditions. The protein's influence on cellular structure and signaling makes it a significant target for understanding and potentially treating these conditions.