Abcam, ab204991, Anti-ELAVL2 antibody

Size: 100µL
Rabbit Polyclonal ELAVL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ELAVL2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ELAVL2. The exact immunogen used to generate this antibody is proprietary information.Q12926

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELAVL2 also known as HuB or Hel-N1 is an RNA-binding protein with a molecular weight of approximately 39 kDa. ELAVL2 binds to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs which affects mRNA stability and translation. The expression of ELAVL2 occurs mainly in the nervous system particularly in neurons where it regulates neuronal differentiation and function. Its precise expression in neural tissues suggests it plays a role in neurodevelopment.
Biological function summary
ELAVL2 modulates the post-transcriptional regulation of mRNA influencing processes like mRNA localization stabilization and translation within neurons. It forms part of ribonucleoprotein complexes that manage the life cycle of mRNAs. Through its interaction with specific mRNA targets ELAVL2 affects the translation of proteins that are essential for synaptic plasticity and neuronal connectivity which are critical processes in maintaining healthy brain function.
Pathways
ELAVL2 integrates into pathways that include the regulation of neuronal mRNA surveillance and synaptic signaling. In these pathways ELAVL2 interacts with related proteins such as ELAVL1 and ELAVL3 which also bind to RNA. These proteins share a common function in maintaining the balance of mRNA levels within neurons. ELAVL2's role in synaptic signaling highlights its involvement in the transmission of information across synapses important for learning and memory.
ELAVL2 has associations with neurological conditions like Alzheimer's disease and autism spectrum disorders. Studies indicate its altered regulation can affect mRNA metabolism in neurons potentially contributing to these disorders. ELAVL2's interaction with proteins such as Tau in Alzheimer's disease or various mRNA targets in developmental disorders reveals its significant position in the pathology of neural conditions where it alters post-transcriptional gene regulation.