Abcam, ab205200, Anti-STYX antibody [EPR16314]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal STYX antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16314,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein STYX (Serine/threonine/tyrosine-interacting protein) also known as PTPN23 functions as a pseudo-phosphatase meaning it has structural resemblance to phosphatases but lacks catalytic activity. STYX acts by binding to substrates and competing with active phosphatases. The molecular mass of STYX is approximately 55 kDa. Expression of STYX occurs widely found in tissues such as brain heart and testis as well as in various transformed cell lines.
Biological function summary
STYX contributes to cellular processes like signal transduction and development by modulating signaling pathways through its interaction with phosphorylated tyrosines. Although not part of a functional enzyme complex due to its pseudo-activity STYX interacts with components involved in kinase signaling. These interactions can act as a regulatory mechanism impacting various cellular functions.
Pathways
STYX influences several signaling cascades particularly the MAPK and Wnt pathways. It exerts its effects by interacting with proteins such as MAP kinase kinase (MEK) and β-catenin integral components of these pathways. Through these interactions STYX affects cell proliferation differentiation and apoptosis indicating its important role in cellular communication and response mechanisms.
Aberrant regulation of STYX associates with cancer and neurodegenerative diseases. In cancer overexpression or mutation of STYX can impact the MAPK pathway leading to dysregulation of cell division and growth. Additionally in neurodegenerative disorders like Alzheimer's disease altered STYX function relates to abnormal phosphorylation states and interactions with proteins such as Tau contributing to disease pathology.