Abcam, ab205490, Alexa Fluor® 488 Anti-Ym-1 + Ym-2 antibody [EPR15263]

Size: 100µL
Rabbit Recombinant Monoclonal CHIL3 antibody - conjugated to Alexa Fluor® 488. Suitable for ICC/IF and reacts with Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15263,
Isotype:IgG,
Conjugation:Alexa Fluor® 488,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ym-1 and Ym-2 also known as chitinase-like proteins exhibit mechanical roles in the immune system without enzymatic chitinase activity. Ym-1 with a mass of approximately 43 kDa and Ym-2 are expressed predominantly in macrophages especially within inflammatory and allergic contexts. Expression is induced by IL-4 and IL-13 cytokines. Both proteins may also show presence in neutrophils and other innate immune cells during particular immune responses marking them important players in immune modulation.
Biological function summary
Ym-1 and Ym-2 regulate tissue repair and remodeling. They play an important role in cell proliferation and matrix formation which is actively involved in tissue homeostasis and wound healing. These proteins are not typically found as part of a larger complex but may interact with multiple signaling molecules in the cell's microenvironment. Their functions in shaping the extracellular matrix and facilitating cell migration make them significant in resolving inflammation.
Pathways
Ym-1 and Ym-2 are involved in the Th2 immune response and arginase pathways. They are associated with the regulation of Th2 cytokine production a pathway interconnected with adaptive immune responses to parasitic infections and allergic reactions. Ym proteins align with arginase pathways important in tissue repair and fibrosis and often correlate with Arginase-1 especially during inflammation and healing processes.
Ym-1 and Ym-2 connect predominately to asthma and fibrosis. Elevated levels observed in these conditions indicate their involvement in disease progression. In asthma Ym proteins modulate airway inflammation and remodeling collaborating with proteins like TGF-β to influence fibrosis and extracellular matrix deposition. The interaction between Ym proteins and such growth factors outlines their participation in pathological conditions offering potential targets for therapeutic interventions.