Abcam, ab205537, Anti-KA1 antibody [EPR18322]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal KA1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18322,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The KA1 domain also known as the Kinase Associated-1 domain is an important structural component in certain proteins. The KA1 domain exhibits a molecular mass of approximately 8-10 kDa depending on its specific protein context. It plays an important role in targeting and binding within the cell. The KA1 domain is expressed in various cell types particularly those in the brain and muscle tissue where it contributes to cellular signaling and function.
Biological function summary
The KA1 domain of proteins helps regulate several important cellular processes. It is often part of larger protein complexes where it assists in localization and anchoring to specific structures in the cell. The domain influences various cellular activities including the assembly of signaling molecules and interaction with phospholipids. By contributing to the regulation of protein kinases and phosphatases the KA1 domain maintains critical cellular functions across different cell types.
Pathways
The KA1 domain integrates into the regulation of mitogen-activated protein kinase (MAPK) pathways and protein kinase A (PKA) signaling. These pathways play essential roles in cell growth apoptosis and other signaling processes. The KA1 domain often collaborates with other proteins such as PKC (Protein Kinase C) to maintain proper signaling cascade function and ensure accurate cellular responses.
The KA1 domain's function can link to neurodegenerative diseases and cancer. Alterations in proteins containing the KA1 domain have been associated with unregulated cell growth or improper signaling cascades often seen in cancerous tissues. The KA1 domain also interacts with proteins like tau in neurons potentially impacting neurodegenerative conditions by affecting cell signaling and structure. These interactions highlight the KA1 domain's importance in contributing to disease pathways and inform therapeutic targets.