Abcam, ab205776, Alexa Fluor® 647 Anti-TAF15 antibody [EPR9197(B)]

Size: 100µL
Rabbit Recombinant Monoclonal TAF15 antibody - conjugated to Alexa Fluor® 647. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9197(B),
Isotype:IgG,
Conjugation:Alexa Fluor® 647,
Excitation/Emission:Ex: 650nm, Em: 665nm,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF15 also known as TATA-binding protein-associated factor 15 is a RNA polymerase II-associated factor with approximate mass of 56 kDa. It belongs to the FET family of proteins which include FUS and EWS. This protein expresses widely in various tissues including the brain and immune cells. Mechanically TAF15 participates in transcription by mediating interactions between transcription factors and the RNA polymerase II complex.
Biological function summary
The protein helps regulate transcription initiation and elongation. TAF15 operates as a part of the transcription pre-initiation complex working closely with other transcription-associated factors to control gene expression. Its role extends beyond the nucleus as it may participate in RNA processing and transport due to its ability to bind RNA.
Pathways
TAF15 plays a role in the regulation of transcription from RNA polymerase II promoters. It interacts with numerous other proteins such as TFIID and RNA polymerase II subunits facilitating transcriptional regulation. TAF15 also associates with pathways related to stress response and cellular growth emphasizing its role in maintaining cellular integrity and function.
TAF15 links to certain forms of cancer and neurodegenerative diseases. Its misregulation or mutation associates with some sarcomas indicating a role in tumorigenesis possibly through interactions with oncogenic proteins like EWS. In neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) TAF15 might be implicated potentially through pathways shared with proteins like TDP-43 that are involved in RNA metabolism dysfunction.