Abcam, ab205884, Anti-Syndecan 2/HSPG antibody

Size: 100µg
Rabbit Polyclonal Syndecan 2/HSPG antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SDC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SDC2. The exact immunogen used to generate this antibody is proprietary information.P34741

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syndecan-2 also known as HSPG (Heparan Sulfate Proteoglycan) protein is a cell surface proteoglycan commonly found in many tissues. It weighs approximately 48- to 50-kDa. Syndecan-2 has a transmembrane core protein and is characterized by the attachment of heparan sulfate glycosaminoglycan chains. It expresses in various cell types including fibroblasts epithelial cells and neuronal cells. This protein binds to extracellular matrix components and growth factors following its structural attributes.
Biological function summary
Syndecan-2 interacts with multiple partners to regulate cellular processes. It is often part of a larger complex involving extracellular matrix proteins and growth factors. Syndecan-2 modulates cytoskeleton organization cell adhesion and migration. Its activity plays significant roles in tissue repair and development because of its involvement in signal transduction via these interactions. Numerous research studies suggest its regulatory impact on cell morphology and signaling events.
Pathways
Syndecan-2 is heavily implicated in several important biological signaling cascades. The protein significantly influences the Wnt signaling pathway which governs cell proliferation differentiation and migration. Another key pathway involving Syndecan-2 is the Rho family of GTPase pathway where it interacts with proteins like Rac1 and Cdc42 to mediate actin cytoskeleton dynamics. These pathways associate Syndecan-2 with cellular responses to extracellular signals contributing to its role in tissue homeostasis.
Syndecan-2 expressions and functions associate with tumor growth and metastasis particularly in cancers such as colorectal and breast cancer. The protein affects tumor microenvironment remodeling facilitating cancerous invasion and dissemination. Additionally Syndecan-2 links to inflammatory diseases like atherosclerosis where it contributes to vascular damage and inflammation. In these conditions Syndecan-2 interactions with other proteins such as integrins exacerbate pathogenic processes.