Abcam, ab205926, Anti-p38 gamma/MAPK12 antibody [EPR6528(N)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal p38 gamma/MAPK12 antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6528(N),
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The p38 gamma protein also known as MAPK12 is a serine/threonine-protein kinase belonging to the mitogen-activated protein kinase (MAPK) family. It has a molecular mass of approximately 41 kDa. This protein is heavily expressed in skeletal muscle and heart tissues although expression occurs in other tissues at lower levels. p38 gamma plays a mechanical role in response to stress signals by phosphorylating downstream targets affecting cellular responses such as proliferation and differentiation.
Biological function summary
P38 gamma/MAPK12 influences the regulation of gene expression apoptosis and cell cycle processes. It operates within a specific MAP kinase signaling module that conveys signals from the cellular surface to the nucleus. This protein sometimes works in conjunction with other members of the MAPK family forming complexes that further fine-tune cellular responses under various conditions. Its activities help cells adapt to changes in their environment by modulating transcription factors and other important substrates.
Pathways
The MAPK pathway and the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway both involve p38 gamma/MAPK12. Within these pathways p38 gamma is closely related to proteins such as JNK1 and JNK2 which also respond to stress signals. These pathways are essential for transmitting signals that regulate cellular growth differentiation and stress responses revealing intricacies of cellular adaptation to the environment.
Aberrant activation or dysfunction of p38 gamma/MAPK12 relates to conditions like cancer and cardiac hypertrophy. In cancer p38 gamma can influence tumor progression and metastasis through its impact on cell proliferation and survival. It also interacts with other proteins like MKK3 and MKK6 which serve as upstream activators in oncogenic signaling pathways. In cardiac hypertrophy altered p38 gamma signaling affects cardiac muscle cell growth potentially leading to heart failure. Understanding these connections provides insight into the mechanisms underlying these disorders.