Abcam, ab205949, Anti-TMEM24 antibody

Size: 100µg
Rabbit Polyclonal TMEM24 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human C2CD2L aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human C2CD2L aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14523

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM24 also known as transmembrane protein 24 is an integral membrane protein with approximately 56 kDa mass. It localizes primarily in the endoplasmic reticulum (ER) and is present in a variety of tissues including the brain and pancreas. It plays a role in maintaining lipid homeostasis acting as a lipid transfer protein with the ability to shuttle phosphatidylinositol from the ER to the plasma membrane. TMEM24 has regions that facilitate membrane association and phospholipid transfer which are key for its mechanical function.
Biological function summary
TMEM24 contributes to cellular processes by regulating glucose-stimulated insulin secretion. It does this by forming part of a complex that modulates the availability of membrane lipids necessary for signaling and membrane dynamics. The protein's activity affects the response of pancreatic beta cells influencing insulin release making it an important player in metabolic regulation. TMEM24 also interacts with other proteins involved in lipid metabolism making it essential for energy homeostasis.
Pathways
TMEM24 is important in the insulin signaling and glucose metabolism pathways. It coordinates with proteins such as PI4KIIIβ and E-syts which are important for phosphoinositide lipid synthesis and turnover. These interactions ensure efficient lipid signaling and membrane trafficking contributing to the proper functioning of insulin signaling. TMEM24's role in these pathways underlines its importance in managing cellular lipid levels and energy balance.
TMEM24 has been implicated in metabolic disorders like type 2 diabetes. Its functional interaction with proteins involved in lipid signaling and insulin secretion such as INS and IRS-1 points to its involvement in glucose homeostasis and pancreatic beta-cell response. Alterations in TMEM24 expression or function may lead to impaired insulin secretion and insulin resistance contributing to diabetes pathogenesis. Understanding TMEM24's role in these processes may offer insights into potential therapeutic targets for managing diabetes.