Abcam, ab206106, Anti-pro-EGF antibody [EPR14622]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal EGF antibody. Suitable for IP, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14622,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Recognises the Pro-epidermal growth factor chain.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pro-epidermal growth factor (pro-EGF) is a precursor form of the epidermal growth factor often referred to as EGF precursor. This protein has a mass of approximately 175 kDa and is known for its role in cell signaling. Pro-EGF is expressed in various tissues including the kidney salivary glands and the gastrointestinal tract. Upon cleavage it releases the smaller active form of EGF which then modulates numerous cellular processes by binding to the EGF receptor (EGFR).
Biological function summary
Pro-EGF plays a critical role in cellular growth and differentiation. Through its conversion to active EGF it interacts with the EGF receptor initiating a cascade of signaling events. This process regulates processes such as inflammation wound healing and embryonic development. Pro-EGF does not form part of a higher-order complex but acts through interactions with its receptor to elicit biological responses.
Pathways
Pro-EGF's function is integral to the MAPK/ERK signaling pathway. It activates this pathway through EGFR binding promoting cellular proliferation and differentiation processes. Pro-EGF also participates in the PI3K/AKT signaling pathway influencing cell survival and growth. Its interaction with EGFR is closely related to other growth factors like TGF-alpha which share the same receptor binding activity.
Pro-EGF has been linked to cancer and wound healing disorders. Dysregulation of EGF signaling often due to overexpression or mutation of EGFR contributes to various cancers like non-small cell lung cancer. Pro-EGF's connection with EGFR is also critical in chronic wounds where impaired signaling can delay healing. Understanding these interactions helps inform therapeutic strategies targeting EGFR in cancer and regenerative medicine.