Abcam, ab206431, Anti-CEACAM1 + CEACAM6 antibody [EPR19878]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CEAM1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19878,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Carcinoembryonic antigen-related cell adhesion molecules 1 and 6 (CEACAM1 and CEACAM6) are members of the immunoglobulin superfamily. CEACAM1 known also as CD66a or BGP has a mass of approximately 110 kDa. CEACAM6 also referred to as CD66c or NCA is around 37 kDa. Both proteins are broadly expressed on epithelial cells in tissues like the colon and lung. CEACAM1 shows higher diversity in isoforms due to alternative splicing allowing it to modulate diverse functions depending on its form. CEACAM6 expression is typically found on cells of the gastrointestinal tract and in granulocytes.
Biological function summary
CEACAM1 and CEACAM6 act as cell adhesion molecules. These proteins help mediate intercellular adhesion and communication which plays a role in maintaining tissue organization and integrity. CEACAM1 is part of complexes involved in intracellular signaling influencing processes like cell proliferation and apoptosis. CEACAM6 lacks significant intracellular signaling domains but contributes to pathogen binding and immune response modulation. Their ability to bind with other CEACAM family members helps regulate cell-cell and cell-matrix interactions.
Pathways
The CEACAM1 and CEACAM6 proteins play roles in key signaling pathways such as the MAPK/ERK and PI3K/AKT pathways. CEACAM1 links to the MAPK/ERK pathway through its ITIM domain modulating cell growth and survival. CEACAM6 interacts with various kinases influencing the PI3K/AKT pathway aiding in cell migration and evasion of apoptosis. Together these proteins participate in pathways that coordinate cell adhesion and signal transduction sharing connections with proteins like beta-catenin.
CEACAM1 and CEACAM6 have strong associations with cancer development especially colorectal and lung cancers. CEACAM1 plays a role in tumor progression by affecting immune cell function and vascular growth. Its downregulation often links with the tumor’s ability to evade the immune system. CEACAM6 overexpression correlates with tumor invasiveness and poor prognosis impacting its connection to effector proteins such as integrins. Both proteins present potential targets for therapeutic strategies due to their involvement in cancer-related mechanisms.