Abcam, ab206972, Anti-Beta Arrestin 2 + Beta Arrestin 1 antibody [EPR22073]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Beta Arrestin 2 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22073,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen used for this product shares 86% homology with Beta Arrestin 1.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The proteins Beta Arrestin 1 and Beta Arrestin 2 often referred to as Arrestins are multifunctional adaptors important in G protein-coupled receptor (GPCR) regulation. Beta Arrestin 1 has a mass of approximately 47 kDa while Beta Arrestin 2 is about 45 kDa. These proteins are widely expressed in various tissues and play an important role in GPCR signaling by facilitating receptor desensitization internalization and signaling pathways. Their presence is ubiquitous in the body showing expression in tissues like the brain heart and liver.
Biological function summary
These Arrestins participate in signal transduction processes by forming complexes with GPCRs. They serve as scaffolds that can recruit other signaling molecules. This ability to form complexes allows them to mediate downstream signaling pathways impacting cellular responses like cell migration proliferation and apoptosis. They are important in fine-tuning cellular responses and adapting to the external environment.
Pathways
Beta Arrestin 1 and 2 play roles beyond GPCR desensitization involving the mitogen-activated protein kinase (MAPK) pathways and the AKT pathway. They interact with proteins such as ERK1/2 in the MAPK pathway and are implicated in modulating cellular growth and survival signals. Through these pathways Beta Arrestins integrate and coordinate complex signaling networks essential for diverse cellular functions.
Beta Arrestins are relevant to conditions such as heart failure and type 2 diabetes. Their role in GPCR signaling links them to heart failure where abnormal receptor signaling can exacerbate the condition. Additionally in type 2 diabetes alterations in GPCR signaling involving these Arrestins can affect insulin sensitivity. They interact with proteins like G proteins and receptors directly connected to these diseases indicating their significance in pathophysiological processes.