Abcam, ab207914, Anti-STEAP1 antibody [J2D2] - N-terminal

Size: 100µL
Mouse Monoclonal STEAP1 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STEAP1 aa 1-100.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:J2D2,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STEAP1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UHE8

Product details:
This product was changed from ascites to tissue culture supernatant on 20th Jan 2020. Lot numbers higher than GR325188 are from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-By protein-A affinity chromatography, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STEAP1 also known as Six Transmembrane Epithelial Antigen of the Prostate 1 is a plasma membrane protein with a molecular weight around 50 kDa. This protein is expressed primarily in prostate tissues but also in a variety of other epithelial tissues. It plays a mechanical role as a metalloreductase facilitating the reduction of metal ions such as iron and copper across the cell membrane. STEAP1 features a characteristic six transmembrane domain which is important for its activity and localization.
Biological function summary
STEAP1 impacts cellular processes connected to metal ion homeostasis and proliferation. By performing as a metalloreductase it modulates the redox state and availability of metal ions within cells. STEAP1 functions as part of a larger complex interacting with other transmembrane proteins in the regulation of ion transport and reduction reactions. These roles are significant in maintaining cellular metabolism and oxidative balance.
Pathways
STEAP1 is actively involved in pathways related to iron and copper metabolism. It links to the iron uptake and transport pathways ensuring proper cellular iron levels are maintained. STEAP1 also shares functional relationships with proteins such as ferritin which stores iron and transferrin which transports iron in the bloodstream. STEAP1 therefore plays an important part in connecting cellular metabolism to systemic metal homeostasis.
STEAP1 has notable associations with prostate cancer and Ewing's sarcoma. Elevated expression of STEAP1 often correlates with the progression of prostate cancer hinting at a potential role in tumor growth and survival. In Ewing's sarcoma STEAP1 engages in molecular mechanisms related to the disease's pathology. Interaction with proteins such as PCA3 a prostate cancer antigen underlines its involvement in carcinogenic processes and highlights its potential as a therapeutic target in oncology.