Abcam, ab208164, Anti-Ig kappa chain V-ID region 16 antibody [L1C1]

Size: 100µg
Mouse Monoclonal KVD16 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing IGKV1D-16 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:L1C1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing IGKV1D-16 protein. The exact immunogen used to generate this antibody is proprietary information.P01601

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Ig kappa chain V-ID region 16 also known as the immunoglobulin kappa variable region plays a critical role in the immune system. This region is part of the light chain of antibodies contributing to antigen binding and antibody specificity. The kappa chain has a molecular mass of approximately 26 kDa. It is mainly expressed in B lymphocytes which are cells responsible for producing antibodies in response to antigens.
Biological function summary
The Ig kappa chain V-ID region 16 is a component of the immunoglobulin molecule. It contributes to antigen recognition by forming the antigen-binding site with the heavy chain variable region. This region is not part of a complex but rather an essential segment of the immunoglobulin structure that directly interacts with antigens. It allows B cells to recognize a wide variety of pathogens aiding in adaptive immune responses.
Pathways
The Ig kappa chain V-ID region 16 participates in the antibody production pathway a significant process in adaptive immunity. This pathway involves multiple steps with V(D)J recombination being particularly important for generating diverse antibody repertoires. Related proteins in these pathways include immunoglobulin heavy chains and the recombination activating genes (RAG-1 and RAG-2) which play important roles in antibody diversity.
The Ig kappa chain V-ID region 16 is associated with conditions such as multiple myeloma and autoimmune diseases. Abnormal expression or mutation of the kappa chain can lead to the development of these disorders. In multiple myeloma the overproduction of monoclonal kappa chains results in paraproteinemia. In autoimmune disorders incorrect antibody specificity due to aberrations in the kappa region may lead to tissue damage. The Ig kappa chain is often analyzed alongside related proteins like Ig lambda chains to help in understanding and diagnosing these conditions.