Abcam, ab208171, Anti-PACS1 antibody

Size: 100µg
Rabbit Polyclonal PACS1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PACS1 aa 150-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PACS1 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.Q6VY07

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACS1 also known as PACSONE and PACS-1 is a cytosolic sorting protein that plays a role in maintaining intracellular cargo and membrane trafficking. It has a molecular weight of approximately 110 kDa. Expressed in various tissues including brain kidney and liver PACS1 works as a bridge connecting trans-Golgi network (TGN) to endosome trafficking pathways where it helps in targeting proteins for endocytosis and recycling back to the TGN.
Biological function summary
PACS1 interacts with various adaptor proteins to regulate the localization of critical signaling molecules within the cell. Its function involves linking to clathrin and interacting with other proteins to form stable complexes ensuring the proper sorting of cargo proteins. This sorting is essential for cell signaling and responses. PACS1's ability to interact with kinases and phosphatases helps regulate the phosphorylation state of other proteins impacting diverse cellular pathways.
Pathways
PACS1 is involved in key intracellular trafficking and protein modification pathways. In particular it plays a significant role in the endocytic recycling pathway which is important in recycling membrane receptors. It closely interacts with clathrin and adaptor protein complexes. Additionally PACS1 is related to the apoptosis pathway through its regulatory effects on protein kinase C. By influencing these pathways PACS1 helps maintain cellular homeostasis and modulate cell survival and communication.
PACS1 mutations have been linked to PACS1 Syndrome a neurodevelopmental disorder characterized by delayed development and distinctive facial features. Additionally PACS1 has a role in some cancers likely due to its involvement in cell-cycle progression and apoptosis and it may interact with the p53 tumor suppressor protein in these contexts. Understanding the specific pathways and interactions involving PACS1 could help target therapeutic strategies for these conditions.