Abcam, ab210748, Anti-MEK5 antibody

Size: 100µL
Rabbit Polyclonal MEK5 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAP2K5 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAP2K5 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q13163

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEK5 also known as MAP2K5 is a dual specificity protein kinase encoded by the MAP2K5 gene. The protein has a molecular weight of approximately 49 kDa. MEK5 is expressed in various tissues with higher expression levels in the heart skeletal muscle and brain. It functions mechanically by activating and phosphorylating ERK5 a member of the MAPK family thereby playing a role in transmitting signals from the cell surface to the nucleus.
Biological function summary
MEK5 plays a critical role in cell growth and survival. MEK5 does not work alone; it associates with MEK5/ERK5 signaling complex. This complex is significant in mediating cellular responses to growth factors and stress stimuli. MEK5’s activation of ERK5 facilitates regulation of various cellular activities including proliferation and differentiation.
Pathways
MEK5 functions in the ERK5 signaling pathway and the MAP kinase cascade. These pathways are important for transducing extracellular signals leading to specific cellular responses. MEK5 interacts closely with ERK5 (also known as MAPK7) in these pathways helping in the transduction of mitogen signals essential for many cellular processes.
MEK5 has implications in cancer and cardiovascular diseases. Abnormal MEK5 signaling is associated with certain cancer types including prostate cancer where it influences cell proliferation and survival. The MEK5/ERK5 pathway is also linked to cardiovascular diseases such as hypertrophy where it plays a role in the stress response of cardiac cells. In these contexts overactive MEK5 signaling contributes to disease progression or pathogenesis.