Abcam, ab21089, Anti-Kv1.6/RCK2 antibody

Size: 100µg
Rabbit Polyclonal Kv1.6/RCK2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:In human HEK293 cells ab21089 recognised a band of ~58 kDa, the predicted MW of Kv1.6/RCK2 (data not shown). This band was not blocked by the immunising peptide. Additional bands of 100 kDa, 25 kDa and 20 kDa were also recognised.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv1.6 also known as RCK2 or KCNA6 is a voltage-gated potassium channel with a molecular weight of approximately 58 kDa. It plays a role in facilitating the movement of potassium ions across the cell membrane contributing to the restoration of resting membrane potential following action potentials. Kv1.6 is found in a variety of tissues including the brain heart and skeletal muscles. It participates in forming a tetrameric structure typical for voltage-gated potassium channels working alongside other related subunits to exhibit the complete functional properties.
Biological function summary
Kv1.6 contributes to the stabilization of electrical signaling in neurons and muscle cells. It participates in shaping action potentials and regulating neuronal excitability. Kv1.6 forms part of the larger voltage-gated potassium channel complex which modulates membrane potential dynamics and excitability helping ensure proper nervous system functionality and muscle responsiveness.
Pathways
Kv1.6 is involved in the regulation of ion homeostasis and the maintenance of neuronal action potentials. It participates in influencing the duration and frequency of action potentials in neurons by cooperating with other voltage-gated channels such as Kv1.1 and Kv1.2. Kv1.6's activity indirectly affects pathways like the MAPK signaling pathway by participating in the overall electrical activity that may influence signaling cascades critical for cell survival and differentiation.
Kv1.6 has been linked to conditions like epilepsy and hypertension. Alterations in the function or expression of Kv1.6 can disrupt normal neuronal excitability contributing to epileptic phenotypes where excessive neuronal firing occurs. Moreover in hypertension aberrant Kv1.6 activity impacts vascular smooth muscle excitability and contractility. Its relation to proteins such as Kv1.1 in epilepsy highlights its collaborative role in ensuring proper neuronal function while interactions with other ion channels in vascular tissues underline its potential involvement in hypertension.