Abcam, ab210953, Anti-HA1(H5N1) antibody [2B7]

Size: 100µL
Mouse Monoclonal HA1(H5N1) antibody. Suitable for WB and reacts with Influenza A samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2B7,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Influenza A,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab210953 specifically recognizes HA1(H5N1) recombinant protein, but not interacted HA1(H1N1) and HA1(H3N2) recombinant protein in ELISA. Cross-reactivity has not been tested in other H5N1 types.

Product details:
This product was changed from ascites to tissue culture supernatant on 24/01/2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HA1 also known as Hemagglutinin subtype 1 (H5N1) is a glycoprotein with an important role in the influenza virus lifecycle specifically avian influenza H5N1. It has a mass of approximately 63 kDa. The primary mechanical function of HA1 is to mediate viral entry into host cells. It facilitates this by binding to sialic acid receptors on the host cell surface which enables viral attachment and subsequent membrane fusion. HA1 is expressed on the surface of the influenza virus and undergoes conformational changes essential for viral fusion and entry.
Biological function summary
HA1 functions within the viral spike complex known as the Hemagglutinin spike protein which includes HA2. This complex is responsible for the intricate process of virus attachment and entry into host cells. HA1's role in receptor binding is critical for this process making it essential for viral infectivity and host specificity. The precise interaction between HA1 and host cell receptors determines the host range of the influenza virus and is an important factor in cross-species transmission events.
Pathways
HA1 plays a fundamental role in the influenza infection pathway particularly in the receptor-mediated endocytosis of the virus. It works closely with neuraminidase another influenza surface protein which facilitates viral release from infected cells after replication. The balance between HA1's receptor binding and neuraminidase's receptor cleaving activities allows for efficient viral propagation and spread. These interactions highlight HA1's integral part in the viral lifecycle and pathogenicity.
HA1 is central to the pathogenesis of avian influenza H5N1 a highly pathogenic avian influenza strain that impacts both avian and mammalian hosts including humans. This strain can lead to severe respiratory illness and high mortality rates in infected individuals. The interaction of HA1 with host immune responses influences disease severity and outcome. In addition HA1 has potential implications in vaccine development as its antigenic properties are often targeted to induce protective immunity against influenza.