Abcam, ab211464, Anti-NECAB2 antibody [CL0524]

Size: 100µL
Mouse Monoclonal NECAB2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NECAB2 aa 200 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CL0524,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NECAB2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7Z6G3,
Epitope:This antibody binds to an epitope located within the peptide sequence IGRLESKALWFDLQQ (aa 259-273).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NECAB2 also known as N-terminal EF-hand calcium-binding protein 2 binds calcium ions through EF-hand motifs. This protein belongs to a family of EF-hand containing proteins involved in calcium signaling. It has a molecular weight around 45 kDa. NECAB2 is expressed mainly in the nervous system particularly in the brain. Studies show its expression in neurons suggesting a role in synaptic function.
Biological function summary
NECAB2 is involved in calcium-dependent signaling pathways. It associates with other proteins to form complexes impacting cellular processes like neurotransmitter release. NECAB2's role suggests it helps modulate synaptic activity and plasticity due to its involvement in regulating intracellular calcium levels. Its interactions in synaptic regions underline its importance in neural communication.
Pathways
NECAB2 participates in calcium signaling and synaptic signaling pathways. In calcium signaling NECAB2 couples with other proteins like calmodulin affecting intracellular calcium concentrations. In synaptic signaling its interaction with proteins like synaptotagmins impacts neurotransmitter release and synapse maintenance. These pathways highlight NECAB2's role in maintaining neural communication and function.
NECAB2 links to neurological conditions such as autism spectrum disorders and schizophrenia. Studies show altered NECAB2 expression in these conditions possibly disrupting normal synaptic function. Its interactions with proteins like neurexins and neuroligins which are implicated in synapse formation and function might contribute to the pathophysiology of these disorders. Understanding NECAB2 in this context could offer insights into therapeutic targets for related disorders.