Abcam, ab213655, Anti-Uroplakin II/UPII antibody [EPR18799]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Uroplakin II/UPII antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18799,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Uroplakin II (UPII) also known as UPK2 plays a structural role in the epithelial cells of the urinary tract. It has a molecular mass of approximately 15 kDa. UPII is expressed specifically in the urothelium which lines the interior surface of the bladder ureters and renal pelvis. This protein contributes to the asymmetric unit membrane (AUM) which forms specialized plaques essential for maintaining the impermeability of the urothelial barrier.
Biological function summary
Uroplakin II functions as part of the larger uroplakin protein complex. UPII interacts with other uroplakins such as Uroplakin Ia Ib and III contributing to the formation of a multimeric structure that strengthens the urothelial cells' surface. This structure plays a role in cellular stabilization and preventing the passage of toxic substances and pathogens from the urine into the underlying tissue. Consequently it aids in maintaining tissue integrity and ensuring efficient functioning of the urinary system.
Pathways
The uroplakin complex integrates into the pathway of epithelial differentiation. Uroplakin II's association with other uroplakins influences the formation of the AUM which involves the coordinated action of several related proteins such as claudins. The interaction with claudins suggests a potential regulatory role for cell-cell adhesion within epithelial transport pathways. This role might interact with tight junction pathways that are important for maintaining the selective permeability of epithelial layers.
Alterations in Uroplakin II expression link to urothelial carcinoma. Abnormal UPII levels can disrupt the urothelial barrier potentially leading to carcinogenesis. Investigations find connections between UPII and overexpression of proteins such as EGFR which contributes to tumor growth and progression. The association of UPII with bladder cancer emphasizes its potential as a diagnostic biomarker and a target for therapeutic strategies in urothelial malignancies.