Abcam, ab214186, Anti-ZNF312/FEZF2 antibody

Size: 100µL
Rabbit Polyclonal ZNF312/FEZF2 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FEZF2 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FEZF2 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8TBJ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.6 Preservative: 0.09% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF312 also known as FEZF2 (Forebrain Embryonic Zinc Finger-Like Protein 2) is a transcription factor with a mass of approximately 68 kDa. This protein features zinc finger motifs that interact with specific DNA sequences. ZNF312/FEZF2 promotes transcriptional regulation by binding to DNA and influencing gene expression. Researchers have observed expression of this protein mainly in the brain especially in the cerebral cortex of humans and other mammals where it plays an important role in neural development.
Biological function summary
ZNF312/FEZF2 regulates important neuronal differentiation processes. It is part of a transcriptional network that influences cell fate decisions in cortical progenitors. ZNF312/FEZF2 acts as a transcriptional repressor and works in synergy with other transcription factors and co-factors although not a direct part of a stable complex. This regulation supports the proper development of the frontal cortex impacting motor neuron identity and connectivity.
Pathways
ZNF312/FEZF2 fits into pathways such as the Wnt signaling pathway and the Notch signaling cascade which control neurodevelopment and neuronal patterning. ZNF312/FEZF2 interacts with paths involving other proteins like TCF4 and Delta-like ligands coordinating the balance between neural progenitor proliferation and differentiation. This orchestrates the spatial and temporal sequences of cortical neuron generation impacting neuronal network formation.
ZNF312/FEZF2 relates to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Altered expression or mutations of FEZF2 can disrupt neural circuit formation affecting mental processes and behavior. FEZF2 ties to other proteins like Disrupted-in-Schizophrenia 1 (DISC1) with evidence that mutations or dysfunctional interactions impact schizophrenia progression suggesting their role in neuronal tissue morphogenesis.