Abcam, ab214318, Anti-ABI3 antibody

Size: 100µL
Rabbit Polyclonal ABI3 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9P2A4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABI3 also known as the ATP-binding cassette sub-family I member 3 is a protein involved in lipid transport and metabolism. It weighs approximately 34 kDa. This protein is expressed in various tissues most notably in the brain and immune cells. The presence of ABI3 has been noted in microglia which are the brain’s resident macrophages highlighting its significance in central nervous system functioning.
Biological function summary
The protein ABI3 plays an essential role in phagocytic activity which helps in clearing cellular debris and toxins supporting immune response and maintenance of tissue homeostasis. ABI3 integrates into a larger macromolecular complex where it interacts with other proteins to influence phagocytosis efficiency. Such interactions empower ABI3 to modulate inflammatory responses thereby contributing to cellular defense mechanisms.
Pathways
Different cellular processes involve ABI3 especially the PI3K-Akt pathway and the immune response pathways. The PI3K-Akt pathway is critical for cell survival and growth where ABI3 modulates these activities. ABI3 interacts with other proteins in this pathway like AKT1 to impact cellular metabolism and survival decisions. Furthermore its involvement in immune response pathways highlights its role in maintaining cellular health through modulating both inflammation and phagocytosis.
ABI3 has associations with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Its role in affected microglial function directly links to inflammatory processes observed in these conditions. Additionally ABI3 interacts with proteins like TREM2 in microglial cells which research connects to Alzheimer’s disease offering insights into potential therapeutic targets.