Abcam, ab215055, Anti-SH2D2A/SCAP antibody

Size: 50µg
Sheep Polyclonal SH2D2A/SCAP antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus.
Key facts
Host species:Sheep,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NP31

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with PBS at 500µg/mL, Purification technique-Affinity purification Immunogen, Purification notes-The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS), Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH2D2A also known as SCAP is an adapter protein of around 41 kDa mass with a central role in signaling pathways. It contains an SH2 domain that allows it to interact with specific phosphorylated tyrosine residues on other proteins. It has expression mainly in immune cells such as T lymphocytes. It functions by connecting receptors on the cell surface to downstream signaling molecules inside the cell. This makes SH2D2A an important player in transmitting extracellular signals to the cell interior.
Biological function summary
Interactions of SH2D2A affect immune cell activation and differentiation progressing to modulate immune responses. It is not part of a larger complex; instead it acts independently to amplify cellular responses. SH2D2A influences signaling pathways that involve cytokines and other immune modulators regulating the magnitude and direction of cellular activities in the immune system.
Pathways
SH2D2A plays a role in the T-cell receptor signaling and calcium signaling pathways. In the T-cell receptor signaling pathway it interacts with proteins like Lck and ZAP-70 aiding in the activation cascade that leads to T-cell activation. In the calcium signaling pathway SH2D2A can connect to phospholipase C-gamma which ultimately affects intracellular calcium levels and further communication within immune responses.
SH2D2A has associations with autoimmune diseases and immune deficiencies. Its misregulation in autoimmune diseases leads to an inappropriate immune response and tissue damage. Autoimmune disorders such as rheumatoid arthritis have links to SH2D2A due to its interactions with proteins like LAT which participate in overactive immune signaling. In immune deficiencies malfunctioning SH2D2A can result in insufficient immune response making understanding this target essential for therapeutic exploration.