Abcam, ab216629, Anti-Eph receptor B2 antibody

Size: 100µL
Rabbit Polyclonal Eph receptor B2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human EPHB2 aa 100-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EPHB2 aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P29323

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Eph receptor B2 also known as EphB2 is a member of the Eph receptor family which includes a number of receptor tyrosine kinases. It has a molecular weight of approximately 110 kDa. The B2 receptor is strongly expressed in various tissues including the brain spinal cord and developing embryos. These proteins include the Eph protein as well as other B2 proteins. The receptor plays a mechanical role in guiding cell positioning and tissue patterning by interacting with Ephrin ligands specifically ephrin-B2 and ephrin-B3.
Biological function summary
Eph receptor B2 functions in cell-cell communication and is involved in neuronal navigation and synaptic plasticity. It forms part of a complex that brings together ligand-receptor pairs on adjacent cells facilitating bidirectional signaling. The receptor's activation influences neuronal circuitry remodeling and helps in the differentiation of numerous cell types. The B2 protein acting as anti B2 modulates various cell signaling mechanisms essential for normal physiological functioning especially in the nervous system where it contributes to the intricate network of the eph protein interactions.
Pathways
These interactions place Eph receptor B2 in significant signaling pathways such as the MAPK/ERK and PI3K/Akt pathways. These play influential roles in cell proliferation survival and migration. The receptor interacts with numerous proteins including AB25AP through these pathways affecting developmental processes and mature cellular functions. The precise regulation of these pathways is necessary for maintaining homeostasis in complex biological systems especially within the context of the nervous system.
Alterations in Eph receptor B2 expressions have been linked to conditions such as cancer and Alzheimer’s disease. In cancers overexpression of the B2 receptor can contribute to the abnormal growth and metastasis of tumor cells often through mechanisms involving interactions with other tumorigenic proteins like Eph receptor A2. In Alzheimer's disease changes in B2 receptor signaling are associated with disrupted synaptic plasticity leading to cognitive deficits highlighting the importance of the Eph B2 receptor and its interplay with related signaling proteins in disease pathways.