Abcam, ab217059, Anti-PEX1 antibody

Size: 100µg
Rabbit Polyclonal PEX1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PEX1 aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PEX1 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43933

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PEX1 also known as Peroxisomal Biogenesis Factor 1 plays an important role in peroxisomal function. PEX1 has a molecular mass of around 145 kDa and is widely expressed in human tissues. It belongs to the family of ATPases associated with various cellular activities (AAAs) which are essential molecular machines involved in diverse biological processes. PEX1 localizes mainly to the peroxisomes which means it takes part in the mechanics of peroxisome assembly and function.
Biological function summary
PEX1 interacts in collaboration with other peroxisomal proteins to facilitate the import of matrix proteins into the peroxisome. It exists as part of a hetero-oligomeric complex with PEX6 another AAA protein which forms an important part of the peroxisome biogenesis mechanism. PEX1’s function in this complex contributes to the assembly maintenance and selective import operations within the peroxisome which are critical for cellular homeostasis and lipid metabolism.
Pathways
PEX1 contributes significantly within the peroxisomal biogenesis pathway where it works alongside proteins like PEX2 and PEX6 to maintain the functionality of the peroxisomes. This pathway is pivotal in multiple biological functions including plasmalogen synthesis and the breakdown of very-long-chain fatty acids. These processes tie closely with broader cellular metabolic pathways impacting both energy regulation and lipid processing.
Defects in PEX1 are linked to peroxisome biogenesis disorders such as Zellweger syndrome spectrum. These disorders result from compromised peroxisomal function leading to severe clinical symptoms and often fatal outcomes. PEX1 mutations disrupt its interaction with PEX6 impairing peroxisome function. This highlights its important role in peroxisome-related diseases and provides potential targets for future therapeutic strategies to treat these metabolic conditions.