Abcam, ab217808, Anti-CHAC1 antibody

Size: 100µL
Rabbit Polyclonal CHAC1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CHAC1 aa 100 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CHAC1 aa 100 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9BUX1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CHAC1 also known as cation transport regulator-like protein (CHAC) plays a significant role in various cellular processes. It is a protein with an approximate mass of 27 kDa and is widely expressed in human tissues including the pancreas kidney and liver. This protein functions primarily as a γ-glutamyl cyclotransferase responsible for the cleavage of glutathione into 5-oxo-proline and cysteinylglycine therefore influencing cellular redox status and stress responses.
Biological function summary
CHAC1 acts as an important player in cell death regulation and stress response mechanisms. It participates in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. CHAC1 engages in these processes by interacting with and being regulated by ATF4 a transcription factor activated during cellular stress. It does not function as part of a large complex but has interactions with specific stress-related proteins.
Pathways
CHAC1 is involved in the integrated stress response (ISR) pathway particularly under conditions that elicit ER stress. It has a significant role in the amino acid deprivation response pathway. The ISR pathway links CHAC1 with other proteins such as ATF4 and eIF2α and through these interactions it helps regulate cellular adaptation to stress.
CHAC1 has connections to cancer and neurodegenerative diseases. In certain cancer types CHAC1 gets upregulated linking it to the modulation of oxidative stress and apoptosis which are important processes in tumor development and progression. Additionally in neurodegenerative diseases its role in oxidative stress management potentially contributes to neuronal cell death associating it indirectly with proteins like caspase-3 that are involved in apoptotic pathways.