Abcam, ab218209, Anti-FRMD6/Willin antibody

Size: 100µL
Rabbit Polyclonal FRMD6/Willin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FRMD6 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FRMD6 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q96NE9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRMD6 also known as Willin is a protein that functions by acting as a scaffold within cells influencing cell shape and motility. This protein has an approximate mass of 78 kDa. FRMD6 is expressed in multiple tissues including the brain with noticeable presence in neuronal cells. It plays a role in the organization of actin cytoskeleton impacting cell adhesion and polarity.
Biological function summary
FRMD6 influences signaling pathways that regulate growth and differentiation. It contributes as part of a regulatory complex that communicates signals from the extracellular matrix to intracellular pathways. The protein is not known to be part of a stable complex but it interacts dynamically with several cytoskeletal elements during cell signaling events. It assists in transducing signals necessary for maintaining cellular architecture and function.
Pathways
FRMD6 is significantly involved in the Hippo signaling pathway which regulates cell proliferation and apoptosis. This pathway controls tissue growth and cancer development through interaction with proteins like YAP and TAZ. FRMD6 operates upstream within this pathway contributing to the suppression of cell growth by modulating these transcriptional coactivators.
FRMD6 associates with diverse pathological conditions. In cancer aberrant expression or function of FRMD6 interrupts normal Hippo pathway signaling potentially promoting tumorigenesis. Additionally studies have linked FRMD6 with neurological disorders reflecting its expression in neuronal tissues. It connects with proteins like LATS1 and MOB1A in these disorders influencing their roles within the affected pathways.