Abcam, ab218296, SMIFH2 Formin FH2 Domain Inhibitor

Size: 10mg / 25mg / 50mg
MW 377.2 Da, Purity >99%. Cell-permeable inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation (IC 50 = ~15 μM) and processive barbed end elongation. Decreases the affinity of formin for the actin filament barbed end. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
Key facts
CAS number:340316-62-3,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:377.2 Da,
Molecular formula:C15H9BrN2O3S,
PubChem:2258538,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Smifh2,
Biological description:Cell-permeable inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation (IC50 = ~15 μM) and processive barbed end elongation. Decreases the affinity of formin for the actin filament barbed end. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.,
Canonical smiles:C1=CC(=CC(=C1)Br)N2C(=O)C(=CC3=CC=CO3)C(=O)NC2=S,
Isomeric smiles:C1=CC(=CC(=C1)Br)N2C(=O)/C(=C/C3=CC=CO3)/C(=O)NC2=S,
InChi:InChI=1S/C15H9BrN2O3S/c16-9-3-1-4-10(7-9)18-14(20)12(13(19)17-15(18)22)8-11-5-2-6-21-11/h1-8H,(H,17,19,22)/b12-8+,
InChiKey:MVFJHEQDISFYIS-XYOKQWHBSA-N,
IUPAC Name:(5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions