Abcam, ab218316, Anti-2N Tau antibody [EPR21723]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TAU antibody. Suitable for WB and reacts with Recombinant fragment - Human, Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21723,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The specificity of this antibody refers to P10636-8.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 2N Tau protein also known as tau or tau protein is a microtubule-associated protein with a mass of approximately 78 kDa. It stabilizes microtubules and is critical for maintaining the axonal transport in neurons. It is highly expressed in the central nervous system particularly in the neurons and becomes hyperphosphorylated under certain conditions. Tau belongs to the family of microtubule-associated proteins and has six isoforms generated through alternative splicing.
Biological function summary
The microtubule-associated protein tau plays a significant role in neuron stability and function by promoting the assembly and stabilization of microtubules. It achieves this through its binding affinity for tubulin which is necessary for the proper functioning of the neuronal cytoskeleton. Tau does not function as part of a complex but its interaction with microtubules is critical for cellular operations including intracellular transport and signaling.
Pathways
Tau functions in processes essential for cellular transport and microtubule dynamics regulation. It is involved in the MAPK/ERK pathway impacting cellular signaling and stress responses. Tau's regulatory role in microtubule stability connects it with proteins such as tubulin and other microtubule-associated proteins. This interaction ensures proper transmission of signals within neurons and affects cell cycle regulation.
Tau dysregulation and hyperphosphorylation relate closely to Alzheimer's disease leading to neurofibrillary tangles that disrupt neuron function. In Alzheimer's tau's interaction with proteins like beta-amyloid is critical for disease progression. Additionally tau is implicated in frontotemporal dementia where its misfolding and aggregation significantly impact neuronal survival and function disrupting communication with proteins important for brain function.