Abcam, ab219790, Anti-VASH1 antibody [4A3]

Size: 50µg
Mouse Monoclonal VASH1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VASH1 aa 1-150.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4A3,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human VASH1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q7L8A9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Vasohibin-1 (VASH1) acts as a conserved microtubule-associated protein inhibitor showing effects in endothelial cells. VASH1's alternate names include tubulin tyrosine ligase-like family member 1 and angiogenesis inhibitor 1. It has a molecular mass of approximately 41 kDa. VASH1 is found mostly in vascular endothelial cells but its expression extends to various tissues including heart lung and kidney. This protein impacts processes related to blood vessel formation and is vital in controlling angiogenesis.
Biological function summary
VASH1 plays a significant role in balancing angiogenesis by inhibiting excessive blood vessel formation. It functions as a part of the anti-angiogenic VASH1/VEGF complex regulating endothelial cell proliferation and migration. This regulation is essential in maintaining normal vascular function and preventing unnecessary angiogenesis which can lead to pathological conditions. Additionally VASH1 modulates the tubulin detyrosination cycle with tubulin being a major cytoskeletal component.
Pathways
VASH1 is integral to angiogenesis and vascular homeostasis. In the VEGF (Vascular Endothelial Growth Factor) signaling pathway VASH1 counteracts the effects of VEGF ensuring precise vascular development. It associates directly with other angiogenesis-related proteins such as VEGF-A. Furthermore VASH1 intersects with the TGF-beta signaling pathway engaging with components like SMADs which regulate cellular responses during tissue repair and fibrosis.
VASH1's malfunction associates with cancer and cardiovascular diseases. Overexpression of VASH1 often correlates with tumor progression as it may control the blood supply critical for tumor growth. In the context of cardiovascular disorders VASH1 expression links with atherosclerosis through its relationship with inflammatory cytokines like TNF-alpha. Understanding VASH1's role could offer insights into potential therapeutic targets for managing angiogenesis-related diseases.