Abcam, ab220110, Anti-MED6 antibody

Size: 100µL
Rabbit Polyclonal MED6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MED6 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MED6 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O75586

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MED6 also known as Mediator complex subunit 6 is an integral component of the Mediator complex which is essential in the transcription regulation. MED6 has a molecular weight of approximately 26 kDa and can be found expressed in various tissues including liver and kidney. MED6 assists in bridging the regulatory molecules to RNA polymerase II machinery helping control the transcription of specific genes.
Biological function summary
MED6 acts as a component of the larger Mediator complex connecting transcription factors with the RNA polymerase II enzyme. This connection facilitates transcription initiation and regulation processes. The complex structure of the Mediator allows proper assembly with other essential proteins to regulate transcription effectively contributing to important cellular activities.
Pathways
The activity of the MED6 protein aligns closely with key biological pathways such as the Wnt signaling pathway and the MAPK signaling pathway. MED6 operates in concert with other Mediator complex subunits to modulate these pathways coordinating with proteins like beta-catenin in Wnt signaling and ERK proteins in MAPK signaling emphasizing its impact in cellular growth and differentiation processes.
Abnormalities in the function or expression of MED6 have been linked to various cancers including colorectal cancer. Changes in its function can disrupt normal transcription processes influencing the expression of genes critical in tumor progression. Additionally MED6's interactions with other proteins such as those involved in the transcription regulation like p53 can further exemplify its connection to oncogenesis underlining potential therapeutic targets for disease management.