Abcam, ab220392, Anti-AKNA antibody

Size: 100µL
Rabbit Polyclonal AKNA antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AKNA aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AKNA aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q7Z591

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AKNA also known as AT-hook transcription factor is a protein involved in transcriptional regulation. This protein has a mass of approximately 80 kDa. AKNA is expressed in various tissues including lymphoid organs which suggests its role in the immune system. Its activity centers around gene transcription where it may influence the expression of genes involved in immune responses. It has an important role in maintaining cellular processes that involve transcriptional regulation.
Biological function summary
AKNA plays an important role in modulating immune system functions and acts as a transcriptional activator and repressor. It is not part of a large multiprotein complex but has interactions that influence the expression of cytokines associated genes. These functions suggest AKNA's importance in regulating immune responses which could affect lymphocyte activity.
Pathways
AKNA mainly involves itself in the immune regulation and inflammation pathways. It influences the expression of genes responsible for cytokine production which impacts immune signaling and cellular communication. AKNA interacts with proteins like NF-kB a critical factor in responding to inflammation showing its influence in inflammation regulation.
AKNA has connections to autoimmune diseases and immune deficiencies due to its role in regulating immune responses. Aberrant expression or mutations in AKNA may relate to autoimmune pathologies such as lupus where its interactions with NF-kB contribute to dysregulated immune functions. Studying AKNA further could provide insights into therapeutic strategies for targeting these conditions.