Abcam, ab220483, Anti-DHRS2 antibody

Size: 100µL
Rabbit Polyclonal DHRS2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DHRS2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DHRS2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q13268

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHRS2 also known as dehydrogenase/reductase SDR family member 2 is a 28-kilodalton protein involved in oxidoreductase activity. This protein catalyzes the conversion of carbonyl compounds to alcohols using NAD(P)H as a cofactor. DHRS2 is expressed in various tissues with significant levels in the liver and kidney which are key sites for metabolic processes. This wide expression points to its role in metabolic regulation across different physiological systems.
Biological function summary
DHRS2 functions in the cellular metabolism of retinoids and steroids impacting cellular differentiation and proliferation. It acts as part of a complex involved in the detoxification and biosynthesis of compounds in cells. The enzyme facilitates the regulation of intracellular signaling through its action on metabolite processing thereby influencing growth and metabolic homeostasis.
Pathways
DHRS2 plays a role in retinol metabolism and steroid biosynthesis. It interacts with proteins such as retinol dehydrogenases and alcohol dehydrogenases which are important in these pathways. This involvement ensures the regulation of retinoid availability which affects visual and developmental processes and the modulation of steroid hormones which are key for maintaining metabolic functions.
DHRS2 has implications in the development of metabolic disorders and certain cancers. Changes in the expression or activity of DHRS2 may disrupt normal metabolic homeostasis contributing to disorders such as diabetes. Furthermore in cancer DHRS2 associates with proteins like p53 where its altered activity can impact tumor suppression or progression. This suggests DHRS2 as a potential target for therapeutic interventions in these conditions.