Abcam, ab22055, Anti-SARS Envelope Protein antibody - Coronavirus

Size: 100µg
Rabbit Polyclonal VEMP antibody. Suitable for WB and reacts with SARS-CoV samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
Applications overview
Tick: Tested and Guaranteed to work X: Will not work —: No data Reviews: Customers have been successful and shared their AbReview

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.2% Gelatin, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS Envelope Protein also known as E protein plays an essential role in the mechanical structure and function of the coronavirus. The protein has a mass of approximately 8.4 kDa and is expressed in the envelope of the virus. It functions as a viroporin creating ion channels that are important for the virus's lifecycle. These channels facilitate the transport of ions across the viral membrane contributing to the virus's assembly and budding processes.
Biological function summary
The SARS Envelope Protein exhibits significant functionality in viral pathogenesis and host interaction. It forms part of a larger protein complex in the viral envelope works alongside other structural proteins like the membrane (M) protein and nucleocapsid (N) protein. Through these actions the E protein influences coronavirus virulence assisting in virus-host interactions and the evasion of the host immune response.
Pathways
The SARS Envelope Protein actively participates in viral replication and assembly pathways. It interacts with host cell machinery to modulate viral and host processes important for replication. It also potentially influences the NF-kB signaling pathway which can affect host inflammation response. Related proteins include the spike (S) protein which helps the virus attach and enter host cells indicating a combined effort in infection spread.
The SARS Envelope Protein has a direct connection to illnesses such as COVID-19 and Severe Acute Respiratory Syndrome (SARS). The protein's role in viral assembly and immune evasion links it to the severity and transmission of these diseases. It is also connected to the IFN path where it can interfere with the host's interferon response a critical aspect of antiviral defense. These interactions make the SARS Envelope Protein a potential target for therapeutic interventions.