Abcam, ab22070, Anti-West Nile Virus M glycoprotein antibody

Size: 100µg
Rabbit Polyclonal POLG antibody. Suitable for WB, IHC-P and reacts with West Nile virus samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:West Nile virus,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The West Nile Virus M glycoprotein also known as the matrix protein plays a mechanical role in virus assembly and maturation. This protein forms a link between the viral envelope and the nucleocapsid contributing to the structural integrity of the virus. The M glycoprotein has an approximate mass of 8.5 kDa. It is expressed in infected host cells during the viral replication cycle particularly in cells of the mosquito and avian hosts as well as humans and other mammals.
Biological function summary
The M glycoprotein of West Nile Virus interacts with other viral proteins to facilitate viral assembly and release. While not part of a complex it collaborates with the E glycoprotein on the viral envelope. Together these proteins orchestrate the budding process from the host cell membrane ensuring the production of infectious virions. The efficient packaging of viral components relies heavily on the proper functioning of the M glycoprotein.
Pathways
M glycoprotein activity intersects with the viral replication pathway and host immune evasion strategies. This protein indirectly aids in subverting the host's immune response by shielding viral components during assembly. Related proteins include the viral capsid protein which assists in RNA encapsidation and the precursor membrane protein which undergoes cleavage to generate the mature M glycoprotein highlighting its involvement in producing infectious viral particles.
The West Nile Virus M glycoprotein is a factor in the pathogenicity of West Nile fever and neuroinvasive disease. The virus's ability to assemble and propagate in host cells depends on the M glycoprotein directly influencing these disease outcomes. Studies suggest a connection between M glycoprotein and the E glycoprotein in enhancing viral spread and immune system bypass contributing to the severity of West Nile virus infections in humans and animals.