Abcam, ab220826, Anti-SIX2 antibody

Size: 100µL
Rabbit Polyclonal SIX2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SIX2 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SIX2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NPC8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SIX2 also known as Sine Oculis Homeobox Homolog 2 is a transcription factor with a molecular weight of approximately 33 kDa. It contains a homeobox domain that allows binding to specific DNA sequences to regulate gene expression. SIX2 is mainly expressed in the developing kidney and plays an essential role during organogenesis. It is also found in some adult tissues but at lower levels compared to development stages.
Biological function summary
SIX2 influences cell proliferation and differentiation mostly during early kidney development. It partners with co-activators and is an integral component of developmental signaling complexes. In this context SIX2 helps maintain progenitor cell populations in an undifferentiated state which is vital for proper organ formation and function.
Pathways
SIX2 plays an essential role in pathways like Wnt and Pax signaling. These pathways regulate important developmental processes by interacting with proteins such as TCF/LEF and PAX2. Through these interactions SIX2 contributes to controlling cell fate decisions and organ patterning during embryogenesis ensuring proper organ development.
SIX2 is associated with renal agenesis and certain types of congenital abnormalities affecting the kidney and urinary tract. Disruptions in the SIX2 expression or function might lead to the absence of kidney formation. It is also linked to pathological conditions interacting with proteins such as GDNF and RET which can contribute to irregular kidney development or diseases involving kidney hyperplasia.