Abcam, ab220962, Anti-C11orf84 antibody

Size: 100µL
Rabbit Polyclonal C11orf84 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SPINDOC aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPINDOC aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q9BUA3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C11orf84 also known as chromosome 11 open reading frame 84 is a lesser-known protein consisting of 242 amino acids with a predicted mass of approximately 27 kDa. Present in many tissues C11orf84 shows higher expression in the brain indicating a potential role linked to neurological processes. The understanding of this protein's exact mechanical functions is limited but its conservation across species suggests significance in cellular actions.
Biological function summary
C11orf84 interacts within cellular systems and possibly takes part in developing cellular structure and signaling. Reports suggest that it may act within multi-protein complexes but precise details on its complex associations are currently understudied. The presence of C11orf84 is consistent with proteins involved in maintaining cellular organization and perhaps signal transduction pointing to a wider involvement in cell biology.
Pathways
Established connections hint that C11orf84 may have a role in neurological pathways such as neural development or synaptic modulation. While direct association within these pathways requires further research C11orf84's expression in the brain links it to proteins like NLGN1 and SHANK3 known for their roles in neural signaling pathways. These connections suggest that C11orf84 might engage in modulating synaptic adherence and signaling efficiency.
Investigations into C11orf84 suggest potential links to neurological conditions such as autism spectrum disorders and schizophrenia. The commonness of the protein within the brain ties it to neuropsychiatric conditions where dysregulation impacts brain function. Its relation to other proteins like NRG1 which play roles in cognitive disorders provides a starting point for understanding how C11orf84 might contribute to these conditions. Further studies are necessary to clarify the role of C11orf84 in disease pathogenesis and if it represents a potential therapeutic target.