Abcam, ab220985, Anti-TOX2 antibody

Size: 100µL
Rabbit Polyclonal TOX2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TOX2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TOX2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q96NM4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TOX2 also known as Thymocyte Selection-Associated High Mobility Group Box Protein 2 is a transcription factor weighing approximately 53 kDa. It is a nuclear protein expressed mainly in the T-cells of the thymus and spleen with notable expression in the brain and bone marrow. TOX2 belongs to the TOX family of proteins characterized by the presence of a high-mobility group (HMG) domain which facilitates its ability to bind and bend DNA thereby influencing the transcription of target genes.
Biological function summary
TOX2 plays an important role in the development and function of the immune system. It assists in the maturation of T-cells and the differentiation of thymocytes being part of a complex transcriptional network. TOX2 interacts with other transcription factors to modulate gene expression profiles critical for immune responses. It has implications in regulating aspects of inflammation and peripheral tolerance indicating its influence on immune homeostasis.
Pathways
TOX2 integrates into processes that govern T-cell receptor signaling and thymocyte development. It associates with pathways such as the Notch signaling pathway influencing thymocyte lineage decisions. Additionally TOX2 interacts with proteins like GATA3 and RUNX1 which are involved in the regulation of lymphoid cell development and differentiation further emphasizing its role in fine-tuning T-cell development and function.
Alterations in TOX2 expression or function bear connections to autoimmune conditions and certain cancers. Abnormal TOX2 activity has links to autoimmune diseases like systemic lupus erythematosus where it may exacerbate immune dysregulation. Its dysregulation also associates with T-cell lymphomas implicating proteins such as p53 in tumorigenic pathways where TOX2 might disrupt cell cycle control therefore influencing cancer progression.