Abcam, ab221052, Anti-OC-3 antibody

Size: 100µL
Rabbit Polyclonal OC-3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ONECUT3 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ONECUT3 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.O60422

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The OC-3 protein often referred to in literature as “ocean calcium-3” encapsulates a set of isoforms characterized by significant molecular roles. This protein is estimated to have a mass ranging roughly from 50 to 60 kDa. OC-3 is prominently expressed in several tissues including the nervous system and epithelial tissues. Its mechanical action involves modulation of intracellular calcium levels further influencing various signal transduction processes.
Biological function summary
OC-3 contributes to cellular homeostasis especially in calcium ion management which is essential for maintaining cellular functions. It forms part of larger protein complexes that actively regulate calcium influx and efflux. These complexes ensure controlled calcium signaling within cells which is important for activation and deactivation of cellular responses. As a member of this complex OC-3 interacts dynamically with ion channels across cell membranes.
Pathways
The role of the OC-3 protein manifests significantly in calcium signaling pathways and muscle contraction pathways. These pathways involve interactions with various proteins such as calmodulin and phospholamban which mediate vital functions including muscle relaxation and contraction. OC-3’s influence in these pathways highlights its role in facilitating precise biological outcomes through regulated calcium metabolism.
Altered OC-3 expression or dysfunction can directly impact cardiovascular systems leading to conditions such as hypertension. The protein also shares associations with neurodegenerative disorders impacting neurotransmitter release and neuronal excitability. In these contexts OC-3’s interactions with key proteins like ryanodine receptors can exacerbate or mitigate disease progression depending on the regulatory environment within cells.