Abcam, ab221192, Anti-ARMC5 antibody

Size: 100µL
Rabbit Polyclonal ARMC5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARMC5 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARMC5 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q96C12

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARMC5 also known as Armadillo Repeat Containing 5 is a protein encoded by the ARMC5 gene in humans. It has a molecular mass of approximately 102 kDa. The protein features multiple armadillo repeat motifs which aid in protein-protein interactions. ARMC5 predominantly expresses in tissues such as adrenal glands and the pituitary gland indicating its specialized roles in these endocrine tissues.
Biological function summary
ARMC5 plays a role in cellular regulation processes and is part of multiprotein complexes involved in various signaling pathways. It participates in controlling cell proliferation and apoptosis. The protein may influence endocrine tissue development and maintenance reflecting its expression pattern. Moreover ARMC5 influences steroidogenesis impacting the synthesis of steroid hormones in adrenal gland tissues.
Pathways
ARMC5 plays a role in the Wnt signaling pathway and the ACTH signaling pathway both critical for cellular growth and function. In the Wnt pathway ARMC5 interacts with beta-catenin an important protein involved in gene transcription regulation. The involvement in the ACTH signaling pathway points to its influence on cortisol secretion important for the body's stress response.
Mutations in ARMC5 associate with primary macronodular adrenocortical hyperplasia (PMAH) a condition characterized by abnormal growth in adrenal glands leading to excess hormone production. ARMC5 mutations have also been linked to Cushing's syndrome a disorder caused by high cortisol levels. In these contexts ARMC5's interplay with proteins like melanocortin 2 receptor (MC2R) shines a spotlight on its critical function in maintaining endocrine balance and its potential as a therapeutic target.