Abcam, ab221195, Anti-SCYL2 antibody

Size: 50µg
Rabbit Polyclonal SCYL2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCYL2 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SCYL2 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6P3W7

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Purification notes-ab221195 is purified by salting-out and ion-exchange chromatography., Storage buffer-pH: 6 - 8.5Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCYL2 also known by the name SCY1-like 2 is a member of the SCY1-like family of proteins. It has a mass of approximately 110 kDa. SCYL2 is an accessory protein with kinase-like activity but lacks enzymatic function. The protein localizes mainly in the trans-Golgi network and the cytoplasm. It is expressed in various tissues including brain and heart indicating its potential roles in different organs and systems within the body.
Biological function summary
The human SCYL2 protein is involved in cellular trafficking and is part of the coatomer complex which assists in vesicle formation and transport. It helps in clathrin-mediated endocytosis which is important for internalizing molecules like lipids and proteins. SCYL2 interacts with other proteins such as clathrin heavy chain and auxilin demonstrating its role in maintaining cellular homoeostasis and membrane dynamics.
Pathways
SCYL2 participates in the endocytosis and intracellular transport processes. It plays a part in the AP-2 complex pathway which is essential for the vesicle docking and cargo selection. Additionally SCYL2 associates with huntingtin an important protein involved in cellular interactions vital for neuron function and integrity connecting its role to neurological processes.
SCYL2 shows associations with neurological conditions like Huntington's disease. Disruptions in its regulatory functions can affect protein transport and neuron stability potentially leading to neurodegenerative symptoms. SCYL2 also interacts with tau proteins which are relevant in Alzheimer's disease indicating its potential influence in tauopathy-related neuronal deterioration.