Abcam, ab221578, Anti-FAM123B antibody

Size: 100µL
Rabbit Polyclonal FAM123B antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AMER1 aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AMER1 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q5JTC6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM123B also known as AMER1 or WTX is a cytoplasmic protein with a mass of approximately 120 kDa. It is expressed in various tissues including the kidneys lungs and heart. The protein contains several domains that facilitate interactions with other proteins which aids in its role in multiple cellular processes. Due to its ability to bind other proteins FAM123B is largely involved in transcriptional regulation and signal transduction.
Biological function summary
The FAM123B protein influences the Wnt signaling pathway and modulates transcriptional activity in cells. It acts as a regulatory element in this pathway by interacting with beta-catenin playing a role in the degradation process. Through its association with beta-catenin FAM123B helps regulate gene expression that controls cell proliferation and differentiation. The ability of FAM123B to form complexes with other proteins enhances its functional diversity within cellular contexts.
Pathways
The modulation by FAM123B has significant implications within the Wnt signaling and beta-catenin degradation pathways. It interacts with other proteins within these pathways including APC and Axin which are important for maintaining cell stability and growth. The activity of FAM123B ensures proper signal transduction and transcriptional regulation emphasizing its importance in cellular communication and development.
Aberrations in FAM123B are linked to several pathological conditions such as Wilms tumor and colorectal cancer. Dysfunction in the Wnt signaling pathway where FAM123B plays a critical role leads to uncontrolled cell proliferation associated with these diseases. Associations with other proteins such as APC in colorectal cancer highlight the significance of FAM123B in cancer development. Understanding the interactions of FAM123B aids in unraveling the pathophysiology of these diseases.