Abcam, ab221705, Anti-P2X5 antibody

Size: 100µL
Rabbit Polyclonal P2X5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RX5 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human P2RX5 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q93086

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The P2X5 receptor also known as P2RX5 is a member of the P2X family of receptors which are ligand-gated ion channels activated by extracellular ATP. P2X5 is a protein that weighs approximately 53 kDa. It is expressed in various tissues particularly prominent in the immune and nervous system. The receptor facilitates the movement of ions such as calcium sodium and potassium across the cell membrane influencing cellular depolarization and signaling.
Biological function summary
P2X5 plays a significant role in modulating immune responses and synaptic transmission. It forms homomeric or heteromeric complexes with other P2X receptor subtypes like P2X1 and P2X2 affecting its functionality. The receptor's presence in the lymphatic tissues suggests its involvement in lymphocyte proliferation and function. Additionally P2X5 influences neurotransmitter release in neural contexts impacting neuron-to-neuron communication.
Pathways
P2X5 participates prominently in the purinergic signaling pathway and has roles in the immune response pathway. It is involved with related proteins like P2X1 and P2X4 in mediating several physiological functions. In purinergic signaling the activation of P2X5 receptor channels by ATP affects numerous downstream processes involving calcium influx which is critical to the function of both neuronal and immune pathways.
P2X5 has been linked to certain inflammatory conditions and neurological disorders. For instance its pro-inflammatory roles make it a point of interest in studying autoimmune diseases. Furthermore abnormalities in P2X5 activity have been associated with multiple sclerosis implicating it in the demyelination processes. The receptor interacts with pro-inflammatory cytokines and such interactions may exacerbate disease states highlighting the therapeutic potential of targeting P2X5 in treatment interventions.