Abcam, ab221722, Anti-NCAPH2 antibody

Size: 100µL
Rabbit Polyclonal NCAPH2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NCAPH2 aa 350-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NCAPH2 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.Q6IBW4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCAPH2 also known as non-SMC condensin II complex subunit H2 plays an important role in chromosome condensation. It is a part of the condensin II complex and contributes to the structuring and stabilization of chromatin. NCAPH2 has a mass of approximately 99 kDa and is expressed broadly in various tissues including embryonic tissues and adult organs. Its functional role is important in processes that require chromatin reorganization.
Biological function summary
NCAPH2 functions as an important component of the condensin II complex which facilitates proper chromosome segregation during cell division. The protein through its interaction with other condensin subunits C and A oversees the maintenance of chromosome architecture. It also influences mitotic progression by ensuring the accurate separation of sister chromatids. Research shows NCAPH2's involvement in maintaining genome stability highlighting its biological significance.
Pathways
NCAPH2 participates in important cellular pathways such as mitotic chromosome condensation and DNA repair mechanisms. Within these pathways NCAPH2 interacts closely with proteins like SMC2 and SMC4 which form the core of the condensin complexes. Correct functioning of these pathways ensures the integrity of genetic material during cell division preventing aneuploidy and other chromosomal abnormalities.
NCAPH2 has been linked to various conditions including cancer and developmental disorders. Its dysregulation has associations with certain cancers due to its role in maintaining genomic stability where its aberrant expression may lead to improper cell division and tumorigenesis. Additionally connections to Kleefstra syndrome where a disruption impacts chromatin organization suggest NCAPH2's interactions with other chromatin-modifying proteins including histone deacetylases.